#7 Vítejte ve světě epigenetiky!
Dá se zdědit víc, než je zapsáno v
genech? Vítejte ve světě epigenetiky!
Podíváme se, jak prostředí a zážitky
rodičů ovlivňují to, jaký bude jejich potomek, co pro vývoj štěněte znamená
prenatální stres, a jak nám epigenetika může rozšířit pohled na dovoz psů,
množírny i vlastnosti, které štěně zdědí po pracovních rodičích.
Zdroje:
1) Alberts B., Johnson A., Lewis J., Raff M., Roberts K., Walter P. (2002). Molecular Biology of the Cell. 4th edition. New York: Garland Science. https://www.ncbi.nlm.nih.gov/books/NBK21054/
2) Špinka M., Havlíček J., Štolhoferová I., Frynta D. (2024). Etologie. Mechanismy, ontogeneze, funkce a evoluce chování živočichů. Akademia. ISBN:978-80-200-3556-1.
3) Liberman N., Wang S. Y., Greer E. L. (2019). Transgenerational Epigenetic Inheritance: From Phenomena to Molecular Mechanisms. Current Opinion in Neurobiology. https://doi.org/10.1016/j.conb.2019.09.012
4) Dias B. G., Ressler K. J. (2014). Parental olfactory experience influences behavior and neural structure in subsequent generations. Nature Neuroscience. https://doi.org/10.1038/nn.3594
5) Benito E., Kerimoglu C., Ramachandran B. et al. (2018). RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment. Cell Reports. https://doi.org/10.1016/j.celrep.2018.03.059
6) Arai J. A., Li S., Hartley D. M., Feig L. A. (2009). Transgenerational Rescue of a Genetic Defect in Long-Term Potentiation and Memory Formation by Juvenile Enrichment. Journal of Neuroscience. https://doi.org/10.1523/JNEUROSCI.5057-08.2009
7) Cao-Lei L., de Rooij S. R., King S., Matthews S. G., Metz G. A. S., Roseboom T. J., Szyf M. (2020). Prenatal stress and epigenetics. Neuroscience and Biobehavioral Reviews. https://doi.org/10.1016/j.neubiorev.2017.05.016
8) Ambeskovic M., Babenko O., Ilnytskyy Y., Kovalchuk I., Kolb B., Metz G.A.S. (2019). Ancestral stress alters lifetime mental health trajectories and cortical neuromorphology via epigenetic regulation. Scientific Reports. https://doi.org/10.1038/s41598-019-42691-z
9) King S. E., Schatz N. A., Babenko O., Ilnytskyy Y., Kovalchuk I., Metz G. A. S. (2025). Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations. Communications Biology. https://doi.org/10.1038/s42003-024-07444-3
10) Liu X., Nisa K.U., Kong W., Lang Z., Niu Q. (2025). DNA methylation and histone modifications: conserved, divergent, and synergistic epigenetic regulation across plants and animals. Epigenetics Insights. https://doi.org/10.48130/epi-0025-0014
11) Hu Y., Yuan S., Du X., Liu J., Zhou W., Wei F. (2023). Comparative analysis reveals epigenomic evolution related to species traits and genomic imprinting in mammals. The Innovation. https://doi.org/10.1016/j.xinn.2023.100434
12) Cimarelli G., Virányi Z., Turcsán B., Rónai Z., Sasvári-Székely M., Bánlaki Z. (2017). Social Behavior of Pet Dogs Is Associated with Peripheral OXTR Methylation. Frontiers in Psychology. https://doi.org/10.3389/fpsyg.2017.00549
13) Zhang S., Li X., Wang Z., Liu Y., Gao Y., Tan L., Liu E., Zhou Q., Xu C., Wang X., Liu G., Chen H., Wang J.-Z. (2017). Paternal spatial training enhances offspring's cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer's mice. Scientific Reports. https://doi.org/10.1038/s41598-017-01811-3
14) McCreary J. K., Metz G. A. S. (2016). Environmental enrichment as an intervention for adverse health outcomes of prenatal stress. Environmental Epigenetics. https://doi.org/10.1093/eep/dvw013
15) Fernandes M. S. S., Costa M. R., Badicu G., Yagin F. H., Santos G. C. J., Costa J. M., Souza R. F., Lagranha C. J., Ardigò L. P., Souto F. O. (2024). Can Environmental Enrichment Modulate Epigenetic Processes in the Central Nervous System Under Adverse Environmental Conditions? A Systematic Review. Cellular and Molecular Neurobiology. https://doi.org/10.1007/s10571-024-01506-0
16) Del Cerro M. C. R., Pérez-Laso C., Ortega E., Martín J. L. R., Gómez F., Pérez-Izquierdo M. A., Segovia S. (2010). Maternal care counteracts behavioral effects of prenatal environmental stress in female rats. Behavioural Brain Research. https://doi.org/10.1016/j.bbr.2010.01.003
17) Dolinoy D. C., Huang D., Jirtle R. L. (2007). Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0703739104